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Simultaneous occurrence of foetal and neonatal alloimmune thrombocytopenia and neonatal neutropenia due to maternal neutrophilic autoantibodies: a case study and review of the literature
Author(s) -
Taaning Ellen,
Jensen Lise,
Varming Kim
Publication year - 2012
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.2012.02715.x
Subject(s) - neonatal alloimmune thrombocytopenia , medicine , autoantibody , neutropenia , immunology , antibody , pregnancy , fetus , chemotherapy , genetics , biology
Foetal and neonatal alloimmune thrombocytopenia (FNAIT) and neonatal neutropenia caused by maternal autoantibodies against neutrophils are rare disorders. We describe a newborn with severe thrombocytopenia and intracerebral bleeding caused by maternal anti‐HPA‐3a alloantibodies and mild neutropenia caused by maternal autoantibodies against HNA‐1b. This appears to be the first case of simultaneous occurrence of these two conditions. Conclusion: This case report and review of the literature demonstrate that anti‐HPA‐3a antibodies can be overlooked by standard assays.