Premium
Neovascularization in retinopathy of prematurity: opposing actions of neuronal factors GPR91 and semaphorins 3A
Author(s) -
Joyal JeanSébastien,
Omri Samy,
Sitaras Nicholas,
Rivera JoséCarlos,
Sapieha Przemyslaw,
Chemtob Sylvain
Publication year - 2012
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.2012.02692.x
Subject(s) - medicine , retinopathy of prematurity , semaphorin , neuroscience , neovascularization , ophthalmology , angiogenesis , receptor , pregnancy , genetics , biology , gestational age
Abstract Retinopathy of prematurity (ROP) is a major cause of severe visual deficits in children. This review focuses on the role of newly identified factors from retinal neurons, which through their opposing actions on vascular development contribute to ROP. These hypoxia‐generated mediators include the Krebs cycle intermediate, succinate acting via GPR91, and the neuronal guidance molecule Semaphorin 3A. Conclusion: Neuron‐derived factors guide retinal vascularization and are major contributors to the pathogenesis of ROP.