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Incidence of and risk factors for neonatal morbidity after active perinatal care: extremely preterm infants study in Sweden (EXPRESS)
Author(s) -
Dordi Austeng,
Mats Blennow,
Uwe Ewald,
Vineta Fellman,
Thomas Fritz,
Lena HellströmWestas,
Ann Hellström,
Per Holmgren,
Gerd Holmström,
Peter Jakobsson,
Annika Jeppsson,
Katarina Johansson,
Karin Källén,
Hugo Lagercrantz,
Ricardo Laurini,
Eva Lindberg,
Anita Lundqvist,
Karel Maršál,
Tore Nilstun,
Solveig NordénLindeberg,
Mikael Norman,
Elisabeth Olhager,
Ingrid Oestlund,
Fredrik Serenius,
Marija Simić,
Gunnar Sjörs,
Lennart Stigson,
Karin Stjernqvist,
Bo Strömberg,
Kristina Törnqvist,
Margareta Wennergren,
Agneta Wallin,
Magnus Westgren
Publication year - 2010
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.2010.01846.x
Subject(s) - medicine , bronchopulmonary dysplasia , retinopathy of prematurity , necrotizing enterocolitis , pediatrics , intraventricular hemorrhage , gestational age , incidence (geometry) , mechanical ventilation , intensive care , ductus arteriosus , population , periventricular leukomalacia , pregnancy , intensive care medicine , surgery , anesthesia , genetics , physics , environmental health , optics , biology
Abstract Aims: The aim of this study was to determine the incidence of neonatal morbidity in extremely preterm infants and to identify associated risk factors. Methods: Population based study of infants born before 27 gestational weeks and admitted for neonatal intensive care in Sweden during 2004–2007. Results: Of 638 admitted infants, 141 died. Among these, life support was withdrawn in 55 infants because of anticipation of poor long‐term outcome. Of 497 surviving infants, 10% developed severe intraventricular haemorrhage (IVH), 5.7% cystic periventricular leucomalacia (cPVL), 41% septicaemia and 5.8% necrotizing enterocolitis (NEC); 61% had patent ductus arteriosus (PDA) and 34% developed retinopathy of prematurity (ROP) stage ≥3. Eighty‐five per cent needed mechanical ventilation and 25% developed severe bronchopulmonary dysplasia (BPD). Forty‐seven per cent survived to one year of age without any severe IVH, cPVL, severe ROP, severe BPD or NEC. Tocolysis increased and prolonged mechanical ventilation decreased the chances of survival without these morbidities. Maternal smoking and higher gestational duration were associated with lower risk of severe ROP, whereas PDA and poor growth increased this risk. Conclusion: Half of the infants surviving extremely preterm birth suffered from severe neonatal morbidities. Studies on how to reduce these morbidities and on the long‐term health of survivors are warranted.