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Delayed clearance of fetal lung liquid and sodium transport—genetic predisposition not evident yet
Author(s) -
HALLMAN Mikko
Publication year - 2005
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.2005.tb03064.x
Subject(s) - epithelial sodium channel , medicine , genetic predisposition , respiratory distress , fetus , lung , candidate gene , endocrinology , gene , sodium , genetics , anesthesia , pregnancy , biology , chemistry , disease , organic chemistry
Abstract The epithelial Na + channel (ENaC) contributes to the clearance of fetal lung liquid. In premature infants, low ENaC activity and low expression level of α‐ENaC have been associated with respiratory failure. The polymorphism in the α‐ENaC gene remains to be studied as a factor explaining the variation in the incidence of transient tachypnoea or respiratory distress syndrome in the newborn. Conclusion : The study of genetic predisposition to common multifactorial diseases requires analyses of large, well‐defined cohorts for representative variants of relevant candidate genes.