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Turner syndrome: a pattern of early growth failure
Author(s) -
Davenport ML,
Punyasavatsut N,
Gunther D,
Savendahl L,
Stewart PW
Publication year - 1999
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1999.tb14419.x
Subject(s) - medicine , short stature , failure to thrive , turner syndrome , pediatrics , in utero , girl , growth retardation , el niño , growth curve (statistics) , turner's syndrome , early childhood , pregnancy , developmental psychology , fetus , psychology , biology , economics , econometrics , genetics
The purpose of this study was to determine the pattern of early growth in girls with Turner syndrome. Analysis was performed on a total of 464 longitudinal measurements of height, obtained from birth to 8 years of age from 37 girls with Turner syndrome who did not have significant cardiac disease or autosomal abnormalities. All data were obtained prior to the initiation of any hormonal therapy. Mean height SDS fell from ‐0.5 at birth to ‐1.5 at age 1 year and ‐1.8 at age 1.5 years. Growth curves fitted using the first two components of the infancy‐childhood‐puberty model of growth revealed that growth failure was due to (a) mild growth retardation in utero , (b) slow growth during infancy, (c) delayed onset of the childhood component of growth and (d) slow growth during childhood. Physicians should consider the diagnosis of Turner syndrome in any girl with an unexplained failure to thrive or with short stature, even during the first 2 years of life.