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Fractures and phenylketonuria
Author(s) -
Greeves LG,
Magee A
Publication year - 1997
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1997.tb08882.x
Subject(s) - medicine , confidence interval , sibling , relative risk , pediatrics , psychology , developmental psychology
Parent or self‐reported history of fractures in a group of patients aged from 0.3 to 33.6 years on dietary treatment for phenylketonuria was studied by means of a questionnaire. Twenty‐one of 85 patients had a history of fracture compared with 18/98 sibling controls. There was no significant difference in the lifetime risk of fracture between patients and controls (x 2 = 1.43, df = 1, p = 0.23), but a significantly higher risk of fracture was reported over the age of 8y (x 2 = 5.11, df = 1, p = 0.024), with a relative risk of 2.6 (95% confidence interval 1.1, 6.1). We suggest this maybe related either to deterioration in dietary control in this age group or to a cumulative disease‐related or diet‐related reduction in bone mass.