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ELEVATED ERYTHROCYTE ADENOSINE DEAMINASE ACTIVITY IN DOWN'S SYNDROME
Author(s) -
PUUKKA RAIJA,
PUUKKA M.,
LINNA SIRKKALIISA,
JOENSUU T.,
KOUVALAINEN K.
Publication year - 1981
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1981.tb05778.x
Subject(s) - adenosine deaminase , medicine , down syndrome , adenosine , purine , gastroenterology , endocrinology , biochemistry , enzyme , biology , psychiatry
Abstract. Puukka, R., Puukka, M., Linna, S‐L., Joensuu, T. and Kouvalainen, K. (Departments of Clinical Chemistry and Paediatrics, University of Oulu, Oulu, Finland). Elevated erythrocyte adenosine deaminase activity in Down's syndrome. Acta Paediatr Scand, 70:739,.–Erythrocyte ADA activity was measured in 29 cases of Down's syndrome and in 29 age‐ and sex‐matched control subjects. The mean activity (± S.D.) of ADA in Down's syndrome was 1 883±463 mU/g Hb (37°C) and 1 361 ±294 mll/g Hb in the controls. The difference was statistically significant ( p <0.001). The purine metabolism of Down's syndrome patients is discussed.