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BILIRUBIN INHIBITS HEXOSE‐MONOPHOSPHATE SHUNT ACTIVITY OF PHAGOCYTOSING NEUTROPHILS
Author(s) -
THONG Y. H.,
RENCIS V.
Publication year - 1977
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1977.tb07985.x
Subject(s) - medicine , ingestion , pentose phosphate pathway , hexose , bilirubin , shunt (medical) , microbiology and biotechnology , biochemistry , endocrinology , pharmacology , metabolism , enzyme , biology , glycolysis
Abstract. Neutrophil hexose monophosphate (H.M.P.) shunt activity was measured by the conversion of 14C‐1‐glucose to 14 CO 2 during ingestion of polystyrene latex particles. Unconjugated bilirubin at the concentration of 1×10 5 M was found to markedly inhibit H.M.P. shunt activity. Since H.M.P. shunt activity of neutrophils is an important prerequisite of microbicidal function, it is suggested that jaundiced newborns may be more susceptible to bacterial infections.