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Anti‐inflammatory potential of a lipolotion containing coriander oil in the ultraviolet erythema test
Author(s) -
Reuter Juliane,
Huyke Constance,
Casetti Federica,
Theek Carmen,
Frank Uwe,
Augustin Matthias,
Schempp Christoph
Publication year - 2008
Publication title -
jddg: journal der deutschen dermatologischen gesellschaft
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.463
H-Index - 60
eISSN - 1610-0387
pISSN - 1610-0379
DOI - 10.1111/j.1610-0387.2008.06704.x
Subject(s) - erythema , medicine , placebo , dermatology , potency , pharmacology , traditional medicine , chemistry , in vitro , biochemistry , alternative medicine , pathology
Summary Background: Coriander oil is used as an antimicrobial agent and as a natural fragrance. The present study investigated the anti‐inflammatory potency of coriander oil in the ultraviolet (UV) erythema test in vivo. Methods: 40 volunteers were enrolled in this monocentric,randomized,placebo‐controlled double‐blind study.Test areas on the back were irradiated with the 1.5 fold minimal erythema dose UV‐B. Subsequently, the test areas were treated under occlusion for 47 hours with a lipolotion containing 0.5% or 1.0% essential coriander oil. Hydrocortisone (1.0%) and betamethasone valerate (0.1%) in the vehicle served as positive controls.The vehicle was used as place‐bo.The effect of the test substances on the UV‐induced erythema was measured photometrically after 48 hours.Additionally,the skin tolerance of the test preparations was assessed on non‐irradiated skin. Results: Compared to placebo, the lipolotion with 0.5% coriander oil significantly reduced the UV‐induced erythema, but it was not as effective as hydrocortisone. The skin tolerance of both coriander oil concentrations was excellent. Conclusions: The lipolotion containing coriander oil displayed a mild antiinflammatory effect in this study. It could be useful in the concomitant treatment of inflammatory skin diseases.