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Cost‐effectiveness of psoriasis therapy with etanercept in Germany
Author(s) -
HeinenKammerer Tatjana,
Daniel Dietmar,
Stratmann Lioba,
Rychlik Reinhard,
Boehncke WolfHenning
Publication year - 2007
Publication title -
jddg: journal der deutschen dermatologischen gesellschaft
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.463
H-Index - 60
eISSN - 1610-0387
pISSN - 1610-0379
DOI - 10.1111/j.1610-0387.2007.06489.x
Subject(s) - etanercept , dermatology life quality index , medicine , psoriasis , psoriasis area and severity index , quality of life (healthcare) , cost effectiveness , adverse effect , quality adjusted life year , physical therapy , dermatology , tumor necrosis factor alpha , risk analysis (engineering) , nursing
Summary Background: We estimated the cost‐effectiveness of intermittent therapy with etanercept in patients with moderate‐to‐severe plaque‐type psoriasis in comparison to non‐systemic therapy in Germany. Patients and Methods: We performed a cost‐utility analysis using the endpoint costs per quality‐adjusted life year gained (costs/QALY). For this purpose, we adapted a UK‐based Markov model by means of resource use data that we derived from a German cost study. Efficacy data, information on frequency of adverse events and changes in quality of life were derived from three pooled clinical trials. We extrapolated the further course of the disease and its treatment over a 10 year course. Results: For patients with an initial Psoriasis Area and Severity Index (PASI) > 10 and a Dermatology Life Quality Index (DLQI) > 10 the incremental cost‐effectiveness ratio (ICER) for etanercept compared to non‐systemic therapy was 45,491 €/QALY. For patients with PASI and DLQI > 15 costs/QALY were 32,058 € and among patients with severe plaque psoriasis (DLQI and PASI > 20) 18,154 € . Conclusions: According to internationally accepted levels of cost‐effectiveness thresholds, the intermittent treatment of (moderate to) severe plaque‐type psoriasis with etanercept is a cost‐effective measure within the German healthcare system.