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Mandibular and femoral growth alteration after sex hormone disruption in growing mice
Author(s) -
Márquez Hernández RA,
Ohtani J,
Fujita T,
Sunagawa H,
Ishikawa E,
Tsubamoto N,
Kawata T,
Kaku M,
Motokawa M,
Tanne K
Publication year - 2011
Publication title -
orthodontics and craniofacial research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 55
eISSN - 1601-6343
pISSN - 1601-6335
DOI - 10.1111/j.1601-6343.2011.01509.x
Subject(s) - medicine , endocrinology , antagonist , femur , receptor , surgery
To cite this article:
Márquez Hernández RA, Ohtani J, Fujita T, Sunagawa H, Ishikawa E, Tsubamoto N, Kawata T, Kaku M, Motokawa M, Tanne K:
Mandibular and femoral growth alteration after sex hormone disruption in growing mice
Orthod Craniofac Res 2011; 14 :63–69 Structured Abstract Authors – Márquez Hernández RA, Ohtani J, Fujita T, Sunagawa H, Ishikawa E, Tsubamoto N, Kawata T, Kaku M, Motokawa M, Tanne K Objectives – To investigate how mandibular and femoral growth is affected when sex hormone– specific receptor antagonist is administered in growing mice. Materials and methods – Forty C57BL/6J mice were used in this experiment. At 5 days of age, the mice received daily injection of estrogen receptor alpha (ERα), beta (ERβ), or androgen receptor (AR) antagonists, and their body weight was assessed every 4 days. One, four and eight weeks after the initial injection, radiographs of the mandible and femur were taken and measured. Analyses of variance and pairwise comparisons (Fisher) were performed to examine the differences in values measured among the groups. Results – Mandibular growth was affected by ERβ antagonist injection in male mice at 4 and 8 weeks. In female mice, the growth was affected during all the experimental period, when ERβ was administered. Moreover, at 8 weeks, mandibular growth was also affected in male and female mice injected with ERα antagonist and in male mice injected with AR antagonist. Femoral growth was affected during all the experimental period in male and female mice injected with ERβ antagonist. Moreover, at 8 weeks, the growth was affected in male and female mice injected with ERα antagonist and in male mice injected with AR antagonist. Conclusions – Growth of the mandible and femur in mice, in part, is induced in response to the stimulation of ERβ in chondrocytes before and during early puberty. In late and after puberty, the growth is induced by the stimulation of ERα in male and female mice and that of AR in male mice.