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Correlation between Skp2 expression and nodal metastasis in Stage I and II oral squamous cell carcinomas
Author(s) -
Tosco P,
La Terra Maggiore G M,
Forni P,
Berrone S,
Chiusa L,
GarzinoDemo P
Publication year - 2011
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/j.1601-0825.2010.01713.x
Subject(s) - perineural invasion , skp2 , medicine , stage (stratigraphy) , immunohistochemistry , metastasis , basal cell , oncology , pathology , nodal , t stage , overall survival , cancer , biology , paleontology , ubiquitin ligase , biochemistry , ubiquitin , gene
Oral Diseases (2010) 17 , 102–108 Purpose: The aim of this study was to investigate the role of S‐phase kinase associated protein (Skp2) in the development of nodal metastasis and to assess its influence on prognosis in stage I and II oral squamous cell carcinomas (OSCCs). Experimental Design: Seventy‐one patients affected by OSCC (stage I‐II) were observed in the period ranging from March 2003 to December 2006. The research was performed using immunohistochemical and histopathological analysis. Results: The overall survival rate was 89.6% at 3 years, 87% at 5 years and 80.7% at 10 years. Patients with vascular or perineural invasion showed no statistically significant survival difference when compared with the ones with no invasion. The tumour depth of invasion did not prove to be related to the metastatic potential. Nine of the seventeen patients with Skp2 positive nuclei (≥20%) developed nodal metastasis. Conversely, only 6 of the 54 patients with a nuclear positivity lower than 20% developed a laterocervical metastasis ( P = 0.001). When comparing survival curves of Skp ≥ 20% and Skp2 < 20% OSCCs, no significant P value emerged from the statistical analysis. Conclusions: This study is the first to report an important correlation between an Skp2 expression lower than 20% and the capability of the tumour not to develop nodal laterocervical metastases ( P = 0.001).