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Tumor‐associated glycoprotein 72 (TAG‐72) expression in salivary gland neoplasia: an immunohistochemical study using the monoclonal antibody (MAb) CC49
Author(s) -
Epivatianos A.,
Poulopoulos A.,
Kayavis I.,
Papanayotou P.
Publication year - 2000
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/j.1601-0825.2000.tb00111.x
Subject(s) - salivary gland , pathology , adenoid cystic carcinoma , mucoepidermoid carcinoma , medicine , salivary duct carcinoma , immunohistochemistry , adenocarcinoma , carcinoma , parotid gland , monoclonal antibody , submandibular gland , antibody , cancer , immunology
OBJECTIVES: The purpose of this study was to investigate immunohistochemically the expression of tumor‐associated glycoprotein 72 (TAG‐72) using the monoclonal antibody (MAb) CC49 in salivary gland neoplasia and normal salivary glands in an attempt to determine the potential usefulness of MAb CC49 in diagnostic and therapetic applications. MATERIALS AND METHODS: Eighty‐six specimens (21 benign tumors, 41 malignant, and 24 normal salivary glands), fixed in 10% formalin and embedded in paraffin, were retrieved from the files of the Department of Oral Medicine and Oral Pathology at the Dental School of Aristotle University, Thessaloniki, Greece, and were retrospectively studied with hematoxylin and eosin and with the streptavidin‐biotin‐complex method using the MAb CC49. RESULTS: Strong immunoreactivity for TAG‐72 was observed in salivary duct carcinoma, adenocarcinoma, papillary cystadenocarcinoma, low‐grade mucoepidermoid carcinoma, normal submandibular, sublingual, and minor salivary glandS. Weak or no immunoreactivity was found in adenoid cystic carcinoma, basal cell adenocarcinoma, polymorphous low‐grade adenocarcinoma, and normal parotid gland. CONCLUSIONS: Our results suggest the potential use of MAb CC49 in the differential diagnosis of some salivary gland neoplasms in which their histopathologic features overlap, and in the radiation immunolocalization and immunotherapy of malignant tumors that are localized in the parotid gland.