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Costimulation Blockade—A Double‐Edged Sword?
Author(s) -
Maltzman J. S.
Publication year - 2012
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/j.1600-6143.2012.04185.x
Subject(s) - medicine , scopus , abatacept , belatacept , transplantation , effector , t cell , blockade , immunology , antibody , kidney transplantation , medline , kidney transplant , immune system , biology , receptor , rituximab , biochemistry
The author describes the findings of Riella et al (see April issue) and Charbonnier et al (see page 2313) that CTLA4Ig worsens outcomes in regulatory T cell–dependent models of transplantation and discusses how these findings may impact future research and clinical use of related drugs.