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A Novel Model for Post‐Transplant Obliterative Airway Disease Reveals Angiogenesis from the Pulmonary Circulation
Author(s) -
Dutly Andre E.,
Andrade Cristiano F.,
Verkaik Ryan,
Kugathasan Lakshmi,
Trogadis Judy,
Liu Mingyao,
Waddell Thomas K.,
Stewart Duncan J.,
Keshavjee Shaf
Publication year - 2005
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/j.1600-6143.2004.00680.x
Subject(s) - medicine , airway , parenchyma , angiogenesis , transplantation , lung transplantation , lung , disease , pathology , surgery
We present a novel animal model for post‐transplant obliterative airway disease in which the donor trachea is implanted into the recipient's lung parenchyma. Although this procedure is technically more challenging than the heterotopic model of implantation into a subcutaneous pouch, it has several important advantages some of which are the appropriate local environment and the possibility of local immunosuppressive therapy after transtracheal gene, cell or drug delivery. This model has revealed new insights into angiogenic potential of the pulmonary circulation.