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Ureteral Stenosis in HDAF Pig‐to‐Primate Renal Xenotransplantation: A Phenomenon Related to Immunological Events?
Author(s) -
Baldan Nicola,
Rigotti Paolo,
Calabrese Fiorella,
Cadrobbi Roberto,
Dedja Arben,
Iacopetti Ilaria,
Boldrin Massimo,
Seveso Michela,
Dall'Olmo Luigi,
Frison Laura,
Benedictis Giulia De,
Bernardini Daniele,
Thiene Gaetano,
Cozzi Emanuele,
Ancona Ermanno
Publication year - 2004
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/j.1600-6143.2004.00407.x
Subject(s) - medicine , xenotransplantation , ureter , transplantation , stent , kidney , stenosis , urology , kidney transplantation , pathogenesis , pathology , surgery
The aim of this study was to analyze the incidence of ureteral stenosis in a life‐supporting human decay‐accelerating factor (hDAF) transgenic pig‐to‐cynomolgus monkey kidney transplantation model and determine the role of possible immunological events in its pathogenesis.Thirty consecutive bi‐nephrectomized cynomolgus monkeys received a kidney from hDAF transgenic pigs with or without a ureteral stent.Four monkeys were euthanized prematurely after transplantation. In the remaining 26 cases, the mean survival was 24 ± 19 days. Except in one case, there was a close relationship between ureter and kidney in terms of type and severity of rejection. There were six ureteral stenoses; five were repaired by stent positioning and resurgery extended survival for an additional 16 ± 10 days. The stenotic ureters showed diffuse acute humoral xenograft rejection (AHXR), while all cases with no or only focal signs of ureteral rejection never revealed ureteral obstruction.Use of a ureteral stent extends the survival of a xenografted primate, thereby helping to clarify the immunological events surrounding the onset of AHXR in kidneys in long‐term xenograft recipients .