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Study on the Relationship Between Different Cytokines in the Semen of Infertility Patients
Author(s) -
Qian Li,
Sun Gang,
Zhou Baocheng,
Wang Gang,
Song Jicheng,
He HaoMing
Publication year - 2011
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/j.1600-0897.2010.00980.x
Subject(s) - semen , infertility , andrology , normal group , sperm , male infertility , semen analysis , medicine , significant difference , positive correlation , gynecology , biology , pregnancy , genetics
Citation
Qian L, Sun G, Zhou B, Wang G, Song J, He HM. Study on the relationship between different cytokines in the semen of infertility patients. Am J Reprod Immunol 2011; 66: 157–161 Problem The relationship between different cytokines in the semen of infertility patients was investigated. Method of study Fifty‐seven semen samples were collected from infertility and normal group at Lianyungang Maternal and Child Hospital. Routine analysis including determination of the levels of IL‐23, IL‐6, and TNF‐α was carried out. Results Density, percentage of sperm moving forward, activity, survival rate, and proportion of normal morphology of sperm of normal group were significantly higher than those of infertility group ( P < 0.001). Amount and pH of the semen from the two groups showed no difference. However, there is a significant difference in IL‐23 contents of semen in the normal (5.87 pg/mL) and abnormal (11.14 pg/mL) group ( P < 0.001). The correlation coefficients ( R ) of the contents of IL‐23 to IL‐6, IL‐8, and TNF‐α were 0.8706 ( R 2 = 0.758, P < 0.001), 0.9725 ( R 2 = 0.9458, P < 0.001), and 0.9499 ( R 2 = 0.9024, P < 0.001), respectively. Conclusion IL‐23 contents of semen are different in the normal and abnormal group and have positive correlations between IL‐6, IL‐8, and TNF‐α, respectively.