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Association of Vascular Endothelial Growth Factor Gene Polymorphisms with Recurrent Spontaneous Abortion in Chinese Han Women
Author(s) -
Xing Xiuye,
Yan Junhao,
Zhao Yueran,
You Li,
Bian Yuehong,
Chen ZiJiang
Publication year - 2011
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/j.1600-0897.2010.00924.x
Subject(s) - genotype , vascular endothelial growth factor , taqman , allele , abortion , vegf receptors , gene , medicine , gene polymorphism , biology , polymorphism (computer science) , genetics , immunology , endocrinology , andrology , polymerase chain reaction , pregnancy
Citation Xing X, Yan J, Zhao Y, You L, Bian Y, Chen Z‐J. Association of vascular endothelial growth factor gene polymorphisms with recurrent spontaneous abortion in Chinese Han women. Am J Reprod Immunol 2011; 65: 521–525 Problem An association of polymorphism −1154G/A (rs1570360) in vascular endothelial growth factor (VEGF) gene with idiopathic recurrent spontaneous abortion (RSA) has been found in Caucasians. The aim of this study was to examine the association of VEGF −1154 with RSA in a well‐defined group of Chinese Han patients. Method of study The VEGF −1154G/A genotype was detected by real‐time PCR with TaqMan probes. The products were also subjected to gene sequence analysis to validate the PCR results. Results The allele frequencies of VEGF −1154G/A showed no significant difference between RSA patients and the normal controls ( P = 0.183). The frequencies of VEGF −1154G/A genotypes were not significantly different between RSA patients and the normal controls ( P = 0.228). Conclusion Our study revealed that VEGF −1154G/A polymorphism was not associated with the susceptibility to RSA in Chinese Han women.