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The Distribution of CD56 dim CD16 + and CD56 bright CD16 − Cells are Associated with Prolactin Levels during Pregnancy and Menstrual Cycle in Healthy Women
Author(s) -
MartínezGarcía Erika A.,
SánchezHernández Pedro E.,
ChavezRobles Bernardo,
NuñezAtahualpa Lourdes,
MartínMárquez Beatriz T.,
AranaArgaez Victor E.,
GarcíaIglesias Trinidad,
GonzálezLópez Laura,
GamezNava Jorge I.,
Petri Marcelo H.,
VelazquezRodriguez Juan,
SalazarParamo Mario,
DavalosRodriguez Ingrid P.,
DaneriNavarro Adrian,
VázquezDel Mercado Mónica
Publication year - 2011
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/j.1600-0897.2010.00916.x
Subject(s) - prolactin , luteal phase , menstrual cycle , follicular phase , pregnancy , endocrinology , medicine , hormone , receptor , population , gestation , biology , physiology , environmental health , genetics
Citation Martínez‐García EA, Sánchez‐Hernández PE, Chavez‐Robles B, Nuñez‐Atahualpa L, Martín‐Márquez BT, Arana‐Argaez VE, García‐Iglesias T, González‐López L, Gamez‐Nava JI, Petri MH, Velazquez‐Rodriguez J, Salazar‐Paramo M, Davalos‐Rodriguez IP, Daneri‐Navarro A, Vázquez‐Del Mercado M. The distribution of CD56 dim CD16 + and CD56 bright CD16 − Cells are associated with prolactin levels during pregnancy and menstrual cycle in healthy women. Am J Reprod Immunol 2011; 65: 433–437 Problem The pregnancy and menstrual cycle (MC) are the main physiologic events linked to the human reproduction. An adequate neuroendocrine axis is mandatory for the homeostasis in both events. To analyze the distribution of NK, T, Treg cells, expression of their receptors and to associate with hormone levels in pregnant and MC in healthy women. Method of Study We studied two groups of healthy women: 13 pregnant women followed up at 1st, 2nd and 3rd trimesters and 11 women in the 5th and 21st day of the MC. The distribution of NK, T, Treg cells population, expression of their receptors and hormone levels were quantified. Results In pregnant women, we found an association of NK cells CD56 dim CD16 + with prolactin levels. This finding was also was observed for CD56 brigth CD16 − being statistical significant during 1st trimester for both subpopulations. During MC, correlation of CD56 dim CD16 + , CD56 bright CD16 − cells with prolactin in follicular and luteal phase was found. Conclusion This is the first report where these cell subpopulations have been analyzed prospectively. Even we can argue the random effect for the small number of women is interesting that prolactin showed the more consistent correlation with CD56 dim CD16 + , CD56 brigth CD16 − cells during both events studied.