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ORIGINAL ARTICLE: Uterine Leiomyoma is Associated with a Polymorphism in the Interleukin 1‐β Gene
Author(s) -
Pietrowski Detlef,
Thewes Roberta,
Sator Michael,
Denschlag Dominik,
Keck Christoph,
Tempfer Clemens
Publication year - 2009
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/j.1600-0897.2009.00718.x
Subject(s) - genotype , uterine leiomyoma , genotyping , allele , odds ratio , biology , allele frequency , polymorphism (computer science) , gene polymorphism , confidence interval , medicine , gastroenterology , genotype frequency , restriction fragment length polymorphism , leiomyoma , microbiology and biotechnology , genetics , gene , pathology , uterus
Problem To investigate whether polymorphisms in the interleukin‐1β (IL‐1β) gene are associated with uterine leiomyoma. Method of study Case–control study in a collective of 131 patients and 280 controls. Genotyping of the IL‐1β‐511 and IL‐1β‐3954 polymorphism was performed by PCR amplification and subsequent RFLP analysis. Results A significant difference in the allele frequencies of the IL‐1β‐511 C