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Variations in Cervical IL‐10 and IL‐8 Concentrations Throughout Gestation in Normal Pregnancies
Author(s) -
MondestinSorrentino Myriam,
Smulian John C.,
Vintzileos Anthony M.,
Sorrentino David,
Ananth Cande V.,
Sharma Surendra,
Hanzeeh N.
Publication year - 2007
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/j.1600-0897.2007.00468.x
Subject(s) - gestation , medicine , gestational age , pregnancy , obstetrics , reference range , second trimester , third trimester , cytokine , analysis of variance , gynecology , endocrinology , biology , genetics
Problem Data regarding cervical interleukin 18 (IL‐8) and IL‐10 concentrations during pregnancy is limited. Method of study This was a cross sectional study of healthy pregnant women. Specimens were collected from the cervical os secretions. IL‐8 and IL‐10 levels were measured by using enzyme‐linked immunosorbent assay. Median (range) cytokine concentrations were derived for each trimester and compared across trimesters. The relationship between gestational age and cytokine levels was assessed by regression analysis. The mean of the ratios of IL‐8 to IL‐10 was compared in each trimester using anova . Results The median (range) IL‐8 concentrations in cervical secretions were in pg/mL: 1562 (1210–4100), 2460 (1047–4688), 3660 (1451–4748) ( P < 0.0021); the median (range) IL‐10 concentrations in cervical secretions were in pg/mL: 38.3 (6.8–227.9), 10.9 (0–263.3), 9.5 (0–35.6); the mean IL10/IL‐8 × 100 (+/− standard deviation) concentrations were: 3.33 ± 0.65, 1.47 ± 0.41, 0.38 ± 0.52 ( P = 0.0035) during the first, second and third trimesters, respectively. Conclusion The patterns of cervical IL‐8 concentration is inversely related to gestational age, and the ratio of IL‐10/IL‐8 decreases with advancing gestation.