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Preeclampsia: the Death of Goliath
Author(s) -
Feinberg Bruce B.
Publication year - 2006
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/j.1600-0897.2005.00362.x
Subject(s) - preeclampsia , proinflammatory cytokine , trophoblast , oxidative stress , pathophysiology , mechanism (biology) , apoptosis , medicine , immune system , immunology , necrosis , inflammation , bioinformatics , biology , placenta , pregnancy , fetus , genetics , philosophy , epistemology
In this review, a novel and unifying pathophysiologic mechanism of preeclampsia is presented whereby a minimal excess of placental immune complex production versus removal causes a proinflammatory autoamplification cascade of trophoblast apoptosis/necrosis and oxidative stress, culminating in clinical preeclampsia. This concept immediately leads to a plethora of new and robust therapeutic strategies.