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Decreased Expression of Endometrial Decay Accelerating Factor (DAF), a Complement Regulatory Protein, in Patients With Luteal Phase Defect
Author(s) -
KAUL ANIL,
NAGAMANI MANUBAI,
NOWICKI BOGDAN
Publication year - 1995
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/j.1600-0897.1995.tb00947.x
Subject(s) - decay accelerating factor , luteal phase , endometrium , immunohistochemistry , infertility , endocrinology , andrology , medicine , complement system , biology , chemistry , hormone , antibody , immunology , pregnancy , genetics
PROBLEM : We investigated the level of decay accelerating factor (DAF) in the endometrium of luteal phase defect (LPD) patients, before and after treatment with progesterone. METHODS : Endometrial samples from fourteen normal‐cycling controls and six samples from infertility patients with LPD before and four samples after progesterone treatment were stained by anti‐DAF IgG using immunohistochemistry. RESULTS : Mean DAF OD in LPD patients was 15% compared to 60% in the control group. The mean DAF OD was 88% after treatment with progesterone. CONCLUSION : Results support interpretation that progesterone upregulates DAF while decreased progesterone may be associated with reduced expression of the DAF in LPD patients.