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The Effect of Cyclophosphamide Pulses on Fertility in Patients With Lupus Nephritis
Author(s) -
LANGEVITZ PNINA,
KLEIN LIORA,
PRAS MORDECHAI,
MANY AMIRA
Publication year - 1992
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/j.1600-0897.1992.tb00780.x
Subject(s) - cyclophosphamide , amenorrhea , lupus nephritis , medicine , fertility , menopause , physiology , pulse (music) , nephritis , endocrinology , gynecology , pregnancy , chemotherapy , biology , disease , population , environmental health , detector , electrical engineering , genetics , engineering
The effect of cyclophosphamide pulse therapy given in relatively small doses (10 mg/kg per pulse) in 17 females with lupus nephritis has been studied. Four females developed menopause; in one transient amenorrhea occurred. No changes in menstrual cycle were noted in the other 11 females, four of whom subsequently delivered five normal babies. These data suggest the relative safety of small doses of cyclophosphamide pulse therapy on gonadal function in females under age 40 years.