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Clinical Experience With the Prevention of Rh‐lsoimmunization: A Historical Comparative Analysis
Author(s) -
KEITH LOUIS,
DANIS RONALD P.,
BERGER GARY S.
Publication year - 1984
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
eISSN - 1600-0897
pISSN - 0271-7352
DOI - 10.1111/j.1600-0897.1984.tb00294.x
Subject(s) - clinical trial , medicine , disease prevention , immunization , pathogenesis , disease , antibody , intensive care medicine , immunology , pediatrics
Clinical experience with prevention of Rh‐immunization is reviewed. The pathogenesis of hemolytic disease and the chemistry of prophylaxis is explained. The factors which effect antigenic expression are delineated. The clinical indications for prevention of AMIS are reviewed. International data pertaining to Rhesonativ are presented from postpartum trials and antepartum trials. A protocol for antepartum administration of anti‐Rh immunoglobulin is given.