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Physical activity counteracts increased whole‐body protein breakdown in chronic obstructive pulmonary disease patients
Author(s) -
Petersen A. M. W.,
Mittendorfer B.,
Magkos F.,
Iversen M.,
Pedersen B. K.
Publication year - 2008
Publication title -
scandinavian journal of medicine and science in sports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.575
H-Index - 115
eISSN - 1600-0838
pISSN - 0905-7188
DOI - 10.1111/j.1600-0838.2007.00727.x
Subject(s) - copd , medicine , pulmonary disease , endurance training , pulmonary rehabilitation , c reactive protein , physical therapy , inflammation
Chronic obstructive pulmonary disease (COPD) is associated with increased whole body protein breakdown and low‐grade systemic inflammation. We aimed to determine if physical training of patients with COPD induces anti‐inflammatory effects and decreases whole‐body protein breakdown. Nineteen subjects with severe (FEV 1 =31±1) COPD were randomized into a training group ( n =9) and a control group ( n =10). Twenty healthy subjects were studied for baseline comparison. The “COPD training” group participated in an outpatient rehabilitation program consisting of endurance training (walking at 85% of VO 2max ) twice weekly for 7 weeks plus daily home‐based training. Maximum walking distance increased by almost 70% in the training group after 7 weeks of training. At baseline, the concentrations of C‐reactive protein (CRP) and IL‐18 in plasma were increased in subjects with COPD compared with healthy subjects ( P <0.05) and leucine rate of appearance ( R a ) was ∼15% greater ( P <0.05) in subjects with COPD. Training had no effect on the plasma concentration of inflammatory markers but decreased leucine R a in subjects with COPD by ∼10% ( P <0.05). In conclusion, 7 weeks of physical training markedly improved endurance in patients with COPD and accelerated whole‐body protein breakdown in patients with COPD was attenuated by physical training independent of changes in inflammatory markers.