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Efficacy of quantitative digital subtraction radiography using radiographs exposed in a multicenter trial
Author(s) -
Jeffcoat M. K.,
Reddy M. S.,
Magnusson I.,
Johnson B.,
Meredith M. P.,
Cavanaugh P. F.,
Gerlach R. W.
Publication year - 1996
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/j.1600-0765.1996.tb00478.x
Subject(s) - radiography , medicine , multicenter trial , randomization , multicenter study , subtraction , nuclear medicine , lesion , dental alveolus , radiodensity , radiology , dentistry , clinical trial , randomized controlled trial , surgery , mathematics , arithmetic
Digital subtraction radiography (DSR) has been shown to be a sensitive and specific method for the detection of small bony changes in periodontitis. The purpose of this study was to perform a multicenter validation of the DSR in human subjects. Seventeen subjects were enrolled at 3 centers. Feather‐edged hydroxyapatite chips (approximately 1,7 and 10 mg) were used to simulate osseous lesions. Bilateral radiographs were taken with and without chips. Geometry was standardized using a cephalostat and the order of radiographs was determined using a randomization plan. Radiographs were subtracted, lesions isolated, and quantified at a single center without knowledge of the randomization code or location of the chips used in each subject. The overall sensitivity and specificity in detecting 1 mg changes was 87.8% and 100%, respectively. Sensitivity and specificity in detecting 7 mg and 10 mg chips was 100%. A strong linear relationship between actual lesion mass and calculated mass was observed (R 2 =0.94, slope=0.98, p<0.0001). No significant differences were observed by center. These data indicate that the DSR is a valid technique for the assessment of alveolar bone changes in multicenter trials.