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Gingival hyperplasia in rats induced by oxodipine ‐ a calcium channel blocker
Author(s) -
Nyska Abraham,
Waner Trevor,
Pirak Michael,
Galiano Alvaro,
Zlotogorski Abraham
Publication year - 1990
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/j.1600-0765.1990.tb00893.x
Subject(s) - calcium channel blocker , hyperplasia , calcium , calcium channel , histology , irritation , medicine , pathology , inflammation , immunology
Oxodipine, a new calcium channel blocker, induced gingival hyperplasia in rats. This is the first time that a calcium channel blocker has been documented as resulting in gingival hyperplasia in rats. In contrast to diphenylhydantoin, the hyperplastic changes induced by oxodipine were not precipitated by any prior irritation. The histology consisted of purely fibroblastic proliferation without infiltrate of inflammatory cells.