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Human antibody‐dependent cellular cytotoxicity and natural killer cytotoxicity in periodontal disease
Author(s) -
Tsoumis G. S.,
Singh Gyan,
Dolby A. E.
Publication year - 1985
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/j.1600-0765.1985.tb00419.x
Subject(s) - antibody dependent cell mediated cytotoxicity , cytotoxicity , periodontal disease , lymphocyte , immunology , antibody , k562 cells , cell , natural killer cell , medicine , biology , dentistry , in vitro , leukemia , biochemistry , monoclonal antibody
Spontaneous cell mediated cytotoxicity (SCMC) and antibody‐dependent cell mediated cytotoxicity (ADCC) were examined in 25 patients with periodontal disease and a group of 25 age and sex matched control subjects. SCMC and ADCC were evaluated from the 51 Cr activity released when peripheral blood lymphocytes were cultured with 51 Cr labelled K562 and L929 cells, respectively. Four lymphocyte: target cell ratios were used, 50: 1, 25: 1, 12.5: 1, and 6.25: 1 in triplicate. There was no significant difference (p>0.05) in the SCMC and ADCC between the two groups. However, a very significant positive correlation (p < 0.001) was found between the degree of periodontal disease (Russell 1956) and SCMC.