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Fibrinolytic activity of gingival epithelium
Author(s) -
Southam J. C.,
Moody G. H.,
Kowolik M. J.
Publication year - 1981
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/j.1600-0765.1981.tb00982.x
Subject(s) - epithelium , gingivitis , fibrinolysis , stratified squamous epithelium , junctional epithelium , plasmin , connective tissue , pathology , periodontitis , medicine , biology , dentistry , enzyme , biochemistry
Specimens of both human and animal gingivae were examined by fibrinolytic autography and all showed lysis over the gingival pocket epithelium, lysis never occurring over oral gingival epithelium. Epithelium separated from the connective tissue also showed fibrinolytic activity confined to the pocket epithelium. Examination of human gingival crevice washings showed fibrinolysis over some nucleated squamous epithelial cells as well as over anuclcated cell fragments. Although ihe neutrophil leucocytes in crevicular washings have fibrinolytic activity, this activity does not compare with that of the epithelium. The fibrinolytic activity of gingival pocket epithelium may be important in the pathogenesis of gingivitis and periodontitis, particularly due to the ability of plasmin lo activate complement.