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The acidic glycosaminoglycans of gingiva of diabetic rats
Author(s) -
Kofoed J. A.,
Tocci A. A.
Publication year - 1973
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/j.1600-0765.1973.tb01124.x
Subject(s) - glycosaminoglycan , heparin , hyaluronic acid , chondroitin sulfate , chemistry , medicine , alloxan , endocrinology , chondroitin sulphate , chondroitin , biochemistry , diabetes mellitus , anatomy
Rats made diabetic by administration of alloxan monohydrate showed in gingiva a 35.9 % reduction in total glycosaminoglycans concentration. The concentration of hyaluronic acid was 48·4 % and that of chondroitin‐4‐sulfate 45·2 % decreased. Heparin concentration was 23·8 % increased. The other sulfate fractions did not appear to be affected. The administration of insulin almost entirely restored the level of the affected glycosaminoglycans to normal values with the only exception of heparin.