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Effect of contraceptive on the periodontal tissue of rats
Author(s) -
Roth Genevieve D.,
Lin Hsien S.,
Liu Frank T. Y.
Publication year - 1972
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/j.1600-0765.1972.tb01720.x
Subject(s) - norethynodrel , mestranol , medicine , dental alveolus , dentistry , connective tissue , population , endocrinology , research methodology , pathology , environmental health , family planning
Two groups of adult female Hollzman rats, injected subcutaneously 5 times a week with low and high doses of norethynodrel plus mestranol for 91 days failed to gain weight at the same rate as the controls. In measuring both the mandibular and maxillary bone loss there was it trend showing the greatest amount of bone loss in the controls, moderate loss in the low dosage and the least loss in the high dosage. The differences of Total mandibular bone loss between the controls and rats treated with high dose of Enovid‐E® were statistically significant. However when the bone loss was measured as a percentage of total mandibular size the differences were not significant. A 2% silver nitrate staining method for delineating the cemento‐enamel junction was developed. Under the present experimental condition; the injection of Enovid‐E® compared to the controls did not demonstrate adverse effects on the gingiva or on alveolar bone.