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Molecular analyses of the candidate tumor suppressor gene, PLAGL1 , in benign and malignant salivary gland tumors
Author(s) -
Enlund Fredrik,
Persson Fredrik,
Stenman Göran
Publication year - 2004
Publication title -
european journal of oral sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.802
H-Index - 93
eISSN - 1600-0722
pISSN - 0909-8836
DOI - 10.1111/j.1600-0722.2004.00174.x
Subject(s) - salivary gland , biology , fluorescence in situ hybridization , chromosomal translocation , adenoid cystic carcinoma , locus (genetics) , tumor suppressor gene , breakpoint , candidate gene , gene , pathology , chromosome , cancer research , genetics , carcinoma , carcinogenesis , medicine , biochemistry
Deletions affecting the long arm of chromosome 6 are a characteristic feature of all major subtypes of malignant salivary gland tumors. Moreover, a subgroup of adenoid cystic carcinomas have t(6;9)(q23‐25;p21‐24) translocations with breakpoints located within the commonly deleted region. Here we have examined the possible involvement of the candidate tumor suppressor gene, PLAGL1 , in these deletions and translocations. Northern blot and fluorescence in situ hybridization (FISH) analyses of a series of 27 salivary gland tumors revealed no significant changes in the gene expression or rearrangements of PLAGL1 . FISH analysis also demonstrated that the 6q translocation breakpoint in adenoid cystic carcinomas with t(6;9) is proximal to the PLAGL1 locus. Collectively, these results indicate that PLAGL1 is not likely to be the major target gene of the 6q rearrangements in salivary gland tumors.