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Hg‐provocation of oral mucosa in patients with oral lichenoid lesions
Author(s) -
Warfvinge Gunnar,
Hellman Mats,
Maroti Marianne,
Ahlström Ulf,
Larsson Åke
Publication year - 1994
Publication title -
european journal of oral sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.802
H-Index - 93
eISSN - 1600-0722
pISSN - 0909-8836
DOI - 10.1111/j.1600-0722.1994.tb01149.x
Subject(s) - oral mucosa , medicine , pathology , oral lichen planus , staining , amalgam (chemistry) , dermatology , chemistry , electrode
Five amalgam‐bearing patients, with clinically and histologically confirmed oral lichenoid lesions, were tested by applying 0.5% Hg in petrolatum for 10 min to clinically normal mucosa. Control sites were exposed to petrolatum only. Four amalgam‐bearing patients with no clinical evidence of oral lichenoid lesions served as controls; they were subjected to similar Hg and petrolatum exposure. After 24 h, biopsies were taken and immunocytochemically analyzed with monoclonal antibodies to lymphoid and nonlymphoid cells. No distinct differences could be detected between the Hg‐exposed areas of the lichen patients and those of the nonlichen patients. Furthermore, normal mucosa exposed to petrolatum only showed a staining pattern in the lichen patients which was no different from the nonlichen patients. The findings are discussed with respect to possible mechanisms of development of lichen‐like lesions in oral mucosa.