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In vitro epithelial cell outgrowth from oral leukoplakia
Author(s) -
SHULER C. F.,
ROEDPETERSEN B.,
REIBEL J.
Publication year - 1981
Publication title -
european journal of oral sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.802
H-Index - 93
eISSN - 1600-0722
pISSN - 0909-8836
DOI - 10.1111/j.1600-0722.1981.tb01691.x
Subject(s) - leukoplakia , pathology , epithelium , hyperkeratosis , epithelial dysplasia , histology , dysplasia , lesion , cell , keratin , premalignant lesion , in vitro , medicine , biology , cancer , biochemistry , genetics
– The appearance of an epithelial cell outgrowth in vitro from biopsies of oral leukoplakia is compared with the histologic appearance of the lesson. Tissue samples from oral leukoplakia of 20 patients were cultured wit te histologic appearance of hte lesion. Tissue samples from oral leukoplakia of 20 patients were cultured to allow the outgrowth of populations of epithelial cells. Adjacent tissue within the lesions was fixed for routine histology. Epithelial cell outgrowth was successful from biopsies possessing the histologic characteristics hyperkeratosis (14 of 20 cases), altered epithelial thickness (14 of 19 cases) and increased mitotic activity (1 of 4 cases). No epithelial cell outgrowth was observed from leukoplakia tissue possessing signs of epithelial dysplasia (0 of 2 cases).