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Calcineurin inhibitor‐associated oral inflammatory polyps after transplantation
Author(s) -
AlMohaya Maha,
Treister Nathaniel,
AlKhadra Ons,
Lehmann Leslie,
Padwa Bonnie,
Woo SookBin
Publication year - 2007
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.2007.00557.x
Subject(s) - calcineurin , tacrolimus , medicine , transplantation , sirolimus , hyperplasia , organ transplantation , pathology
Calcineurin inhibitors (cyclosporine and tacrolimus) have been used as the mainstay immunosuppressive therapy for solid organ and hematopoietic cell transplantations (HCT) to prevent allograft rejection and for prophylaxis and treatment of the chronic graft‐versus‐host disease. Adverse effects of these drugs include nephrotoxicity, hepatotoxicity, neurotoxicity, hypertension and gingival hyperplasia. Association of oral non‐gingival soft tissue hyperplasia with calcineurin inhibitor therapy has only recently been recognized and is thought to occur infrequently. We present four cases of oral non‐gingival inflammatory fibro‐vascular hyperplasias attributed to the use of calcineurin inhibitors following solid organ transplantation and HCT. These lesions interfere with function and must be differentiated from other oral lesions, and therefore should be surgically excised.