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Association between proliferative verrucous leukoplakia and infection with human papillomavirus type 16
Author(s) -
Palefsky Joel M.,
Silverman Sol,
AbdelSalaam Maha,
Daniels Troy E.,
Greenspan John S.
Publication year - 1995
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1995.tb01165.x
Subject(s) - human papillomavirus , premalignant lesion , papillomaviridae , medicine , leukoplakia , pathology , koilocyte , oral leukoplakia , dermatology , biology , virology , cancer , cervical intraepithelial neoplasia , cervical cancer
Proliferative verrucous leukoplakia (PVL) is a recently described clinical entity characterized by multifocal oral lesions that frequently progress to oral cancer despite abstinence from tobacco use by most patients. To determine if this condition is associated with human papillomavirus (HPV), a polymerase chain reaction (PCR) for HPV DNA was performed on 9 lesions from 7 patients with PVL, histologically diagnosed with focal keratosis (1), papilloma (1), epithelial dysplasia (5) and squamous cell cancer (2). Eight (89%) were HPV positive, 7 for HPV 16. For comparison, we studied 55 non‐PVL‐associated oral specimens, including 24 oral squamous cell cancers. Of the cancers, 8 (33%) were HPV positive, 4 for HPV 16. These data suggest that HPV 16 infection may play an important role in the pathogenesis of PVL‐associated oral dysplasia and possibly cancer, but is found in only a small proportion of the more common, non‐PVL associated‐oral lesions.