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HIV‐associated oral lesions; immunologic, virologic and salivary parameters
Author(s) -
Barr Charles E.,
Lopez Marta R.,
RuaDobles Ana,
Miller Lorraine K.,
MathurWagh Usha,
Turgeon Livia R.
Publication year - 1992
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1992.tb01014.x
Subject(s) - medicine , saliva , leukoplakia , immunocompetence , viral disease , immunology , gastroenterology , human immunodeficiency virus (hiv) , cancer , immune system
There are numerous reports of oral lesions in HIV‐infected individuals. However, few correlate the oral lesions with laboratory parameters. This study examined oral candidiasis and hairy leukoplakia, the two most common HIV‐associated oral lesions, in relation to T‐cell counts, p24 core antigen levels and salivary flow rates. Oral mucosal examinations, immunologic and virologic studies and stimulated whole and parotid saliva How rales were conducted on 135 (HIV+= 102, HIV‐ =33) homosexual or bisexual men. Results indicate that, among HIV‐infected subjects, the odds of having oral candidiasis is 6 times (95% CI = 0.6–56.6) greater for subjects with T4 counts between 200–399 per mm 3 , and 23 times (95% CI =2.8–193.0) greater for subjects with T4 counts less than 2007 mm1 compared to subjects with T4 counts of 400/mm 3 or greater. Subjects had an equal likelihood of having hairy leukoplakia at different levels of immunocompetence. The prevalence of oral candidiasis and hairy leukoplakia was higher among subjects with infectious virus in their serum, but was only statistically significant for hairy leukoplakia ( p =0.01).