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Lactate dehydrogenase isoenzymes in squamous cell carcinomas of the oral cavity
Author(s) -
Görögh T.,
Eickbohm J. E.,
Ewers R.,
Lippert B.
Publication year - 1990
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1990.tb00796.x
Subject(s) - lactate dehydrogenase , isozyme , oral cavity , isoelectric focusing , cell , pathology , epithelium , basal cell , biology , enzyme , chemistry , cancer research , microbiology and biotechnology , medicine , biochemistry , orthodontics
Lactate dehydrogenase (LDH; EC 1.1.1.27) isoenzymes in human epithelial cells from squamous cell carcinomas and healthy tissues of the oral cavity of five patients were analyzed using isoelectric focussing. A new basic isoenzyme and high LDH‐7 and LDH‐9 activity were found in tumor cells in contrast to epithelial cells of adjoining nontumor tissue. These findings indicate that gradual changes in the percentage distribution of LDH isoenzymes may represent a useful parameter of disease activity in patients with squamous cell carcinomas.
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