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Lethal effect of male rat submandibular gland homogenate for rat neonates
Author(s) -
Dean D. H.,
Hiramoto R. N.
Publication year - 1985
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1985.tb00544.x
Subject(s) - weanling , submandibular gland , trypsin , medicine , endocrinology , salivary gland , enzyme , adult male , biology , biochemistry
Suckling rats injected subcutaneously with male submandibular gland homogenate (SMGH), but not liver homogenate (L.H), died within 24 h. Weanling and adult rats injected with proportionately greater doses of male SMGH did not die. Suckling rats injected with male SMGH exhibited a I200% increase in scrum trypsin‐like activity while the corresponding increase for an adult receiving a proportionately similar dose was 46%. We suggest that pups injected subcutaneously with SMGH absorbed trypsin‐like enzymes into their bloodstream, were unable to inactivate the enzyme. and suffered a hypotensive crisis leading to death.