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Deposition of immunoglobulin and complement in mucocutaneous lesions related to treatment with D‐penicillamine
Author(s) -
Egeland Torstein,
Brandtzaeg Per
Publication year - 1982
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1982.tb00155.x
Subject(s) - immunohistochemistry , mucocutaneous zone , pathology , basement membrane , medicine , rheumatoid arthritis , antibody , penicillamine , epithelium , vasculitis , staining , immunoglobulin a , dermatology , immunoglobulin g , immunology , disease
A 23‐year‐old man suffering from sero‐negative rheumatoid arthritis developed severe penicillamine‐induced mouth ulcerations and erythematous maeules. Immunohistochemical staining in a biopsy specimen from the affected lingual mueosa showed substantial deposition of IgM and C3 in vessel walls below the necrotic epithelium. In the affected skin, irregular granular staining for IgG and IgM along the epidermal basement membrane zone was noted, and granular deposits of IgM were present in small vessels of dermal papillae. The mouth ulcerations healed promptly after withdrawal of the drug, whereas the macules persisted for some months. The immunohistochemical findings indicated that the drug eruptions were related to a vasculitis induced by deposition of immune complexes.