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A fine structural comparison of the healing of incisional wounds of mucosa and skin
Author(s) -
Sciubba James J.,
Waterhouse John P.,
Meyer Julia
Publication year - 1978
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1978.tb01596.x
Subject(s) - wound healing , basal lamina , epithelium , hemidesmosome , pathology , epidermis (zoology) , lamina propria , oral mucosa , phagocytosis , biology , basal (medicine) , skin repair , cell migration , anatomy , ultrastructure , medicine , cell , immunology , endocrinology , genetics , insulin
Abstract Incisional wounds of the same length and depth were made on tongue and dorsal skin of rats and the fine structural aspects of the responses of these were compared. Comparisons were made between the timing and degree of phagocytosis, the timing and rate of epithelial cell migration, of overall rate of healing, and of reformation of basal lamina and attachment complex in these two tissues. Phagocytic activity in epithelium and connective tissue of mucosa reached higher levels than in skin and the peak of activity in the epithelium of the mucosa was earlier than in the epidermis. Mononuclear phagocytes were active in phagocytosis, neutrophils showed little phagocytic activity‐Epithelial migration was found to begin earlier in mucosa than in skin. Epithelialization of the wound and repair of supporting tissue were completed earlier. The same sequence in the renewal of ultrastructural components of the hemidesmosome‐attachment complex was found in skin and mucosa, but was completed earlier at the mucosal site. Mechanical and physical as well as physiologic factors may play a role in determining the differing rates of repair in mucosa and skin.