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Tuberculosis‐like lesions arising from the use of Freund's complete adjuvant in an owl monkey ( Aotus sp.)
Author(s) -
Málaga Carlos A.,
Weller Richard E.,
Roger Broderson J.,
Gozalo Alfonso S.
Publication year - 2004
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.2004.00060.x
Subject(s) - tuberculosis , medicine , adjuvant , tuberculin , pathology , lung , immunology
Abstract: An apparently normal, non‐tuberculin‐reacting, splenectomized owl monkey presented tuberculosis‐like lesions of the lung at necropsy. Histological and bacteriological examination failed to demonstrate the presence of acid‐fast organisms. Retrospective inquiry showed the animal had been inoculated using complete Freund's Adjuvant during a malaria vaccine trial. Lesions observed were compatible with lipid embolism of the adjuvant in the lungs.