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Early activation of PBMC and appearance of antiviral CD8 + cells influence the prognosis of SIV‐induced disease in rhesus macaques
Author(s) -
Joag S.V.,
Adams R.J.,
Foresman L.,
Gaibreath D.,
Zink M.C.,
Pinson D.M.,
McClure H.,
Narayan O.
Publication year - 1994
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1994.tb00110.x
Subject(s) - peripheral blood mononuclear cell , cd8 , virus , virology , immunology , simian immunodeficiency virus , biology , peripheral blood , immune system , in vitro , biochemistry
We studied 15 macaques inoculated with SIV and identified three phases of infection. Phase 1 was characterized by activated lymphocytes in blood and infected cells in the CSF. In phase 2, activated cells were not detected but virus was recovered from mitogen‐stimulated PBMC, while in phase 3, virus was recovered from mitogen‐stimulated PBMC only after depletion of CD8 + lymphocytes, indicating effective control of the virus in peripheral blood. Early development of phase 3 status correlated with a longer period of clinical normalcy.