Absence of merkel cell polyoma virus in cutaneous melanoma | Zendy

Koburger Ivette | Zendy; Meckbach Diana | Zendy; Metzler Gisela | Zendy; Fauser Uwe | Zendy; Garbe Claus | Zendy; Bauer Jürgen | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Absence of merkel cell polyoma virus in cutaneous melanoma

Author(s) -

Koburger Ivette,

Meckbach Diana,

Metzler Gisela,

Fauser Uwe,

Garbe Claus,

Bauer Jürgen

Publication year - 2011

Publication title -

experimental dermatology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.108

H-Index - 96

eISSN - 1600-0625

pISSN - 0906-6705

DOI - 10.1111/j.1600-0625.2010.01175.x

Subject(s) - merkel cell polyomavirus , merkel cell , melanoma , merkel cell carcinoma , primer (cosmetics) , virus , biology , virology , medicine , pathology , cancer research , carcinoma , chemistry , organic chemistry

Recently, merkel cell polyoma virus (MCPyV) has been described in 80% of merkel cell carcinomas (MCC). Similar to MCC, melanoma incidence is increased in immuno‐suppressed patients. We hypothesized that MCPyV may play a role in melanoma development as well. We selected 95 archival, paraffin‐embedded primary melanomas. DNA was obtained from micro‐dissected tissue and amplified with PCR primer sets specific for the MCPyV T‐antigen locus (LT1 and LT3) and for the VP1 gene. None of the 95 melanoma samples did show LT1, LT3, or VP1 fragment amplification. In conclusion, there is no evidence that MCPyV infection plays a role in cutaneous melanoma development.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research