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Heparin‐induced thrombocytopenia associated with interleukin‐8‐dependent platelet activation in a patient with antiphospholipid syndrome
Author(s) -
Bounameaux Claire,
Boehlen Françoise,
Membré Aurélie,
Genné Daniel,
Pouplard Claire,
Regnault Véronique,
De Moerloose Philippe
Publication year - 2007
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.2007.00959.x
Subject(s) - heparin , heparin induced thrombocytopenia , platelet , medicine , platelet factor 4 , platelet activation , immunology , immunoassay , interleukin 11 , anticoagulant , interleukin , antibody , cytokine
Platelet factor 4 heparin enzyme immunoassay, platelet aggregation test, and serotonin release assay are commonly used to diagnose and confirm heparin‐induced thrombocytopenia. We describe a case of recurrent thrombocytopenia appearing in a few hours after each heparin administration and who tested negative for the three assays. Further analysis revealed anti‐interleukin (IL)‐8 antibodies and IL‐8‐dependent platelet activation facilitated by heparin, which may explain this unusual case of heparin‐induced thrombocytopenia.