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Immunophenotype of hairy‐cell leukemia
Author(s) -
Hassan I. B.,
Hagberg H.,
Sundström C.
Publication year - 1990
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.1990.tb00447.x
Subject(s) - immunophenotyping , cd5 , cd20 , monoclonal antibody , cd19 , cd38 , hairy cell leukemia , antigen , cd22 , monoclonal , immunology , leukemia , b cell , phenotype , microbiology and biotechnology , antibody , medicine , biology , cd34 , genetics , stem cell , gene
15 cases of HCL were studied with a panel of monoclonal antibodies against different leukocyte antigens. A B‐cell phenotype different from that of B‐CLL was observed (CD10 ‐ , CD19+, CD20+, CD21 ‐ , CD22+, CD37+, CD38 ‐ , FMC7+, LN1+, PCA‐1+, BLy7+and CD5 ‐ ). As expected, CD11c and CD25 were positive and, in addition, a My7 and My9 positivity in varying degree was noted. 3 weeks of in vitro incubation did not significantly alter the phenotype. We conclude that HCL exhibits a unique phenotype among chronic B‐cell leukemias, which is closer to the plasma cell stage of differentiation than that of B‐CLL. The BLy7 monoclonal antibody seems to be a promising marker for HCL.