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Reversal of myelofibrosis by hydroxyurea
Author(s) -
Löfvenberg Eva,
Wahlin Anders,
Roos Göran,
Öst Åke
Publication year - 1990
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.1990.tb00344.x
Subject(s) - polycythaemia , myelofibrosis , medicine , thrombopoiesis , myeloproliferative disorders , bone marrow , hydroxycarbamide , platelet , polycythemia vera , bone marrow diseases , gastroenterology , chemotherapy , haematopoiesis , stem cell , megakaryocyte , biology , genetics
Bone marrow morphology in 39 symptomatic patients with myeloproliferative disorders (polycythaemia vera 15, essential thrombocythaemia 14, idiopathic myelofibrosis 9, myeloproliferative syndrome 1) and elevated platelet counts was studied before and after a median of 18 months of continuous treatment with hydroxyurea. We found a significant reduction of bone marrow fibrosis, believed to be mediated by suppression of thrombopoiesis by hydroxyurea.