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Radioprotection by murine and human tumor‐necrosis factor: Dose‐dependent effects on hematopoiesis in the mouse
Author(s) -
Slørdal Lars,
Muench Marcus O.,
Warren David J.,
Moore Malcolm A. S.
Publication year - 1989
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.1989.tb00331.x
Subject(s) - haematopoiesis , tumor necrosis factor alpha , cancer research , tumor necrosis factor α , necrosis , immunology , medicine , biology , stem cell , microbiology and biotechnology
Tumor‐necrosis factor (TNF) has been shown to confer significant radioprotection in murine models. Herein, we demonstrate a dose‐dependent enhancement of hematological recovery when single doses of either murine or human recombinant TNF are administered prior to irradiation. In addition to its action upon leukocytes and erythrocytes, TNF also alleviates radiation‐induced thrombocytopenia in the mouse. These effects on circulating blood constituents are further reflected in increased numbers of both primitive (CFU‐S) and more differentiated (CFU‐GM, CFU‐Mega) hematopoietic progenitors in TNF‐treated animals. This suggests that TNF exerts it radioprotective effects on a pool of primitive multi‐potential hematopoietic cells.