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Stimulus‐specific defect in oxidative metabolism of polymorphonuclear granulocytes in polycythemia vera
Author(s) -
Samuelsson Jan,
Lindström Peter,
Palmblad Jan
Publication year - 1988
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.1988.tb00227.x
Subject(s) - oxidative metabolism , granulocyte , stimulation , chemotaxis , oxidative phosphorylation , polycythemia vera , stimulus (psychology) , respiratory burst , metabolism , endocrinology , medicine , chemistry , immunology , biochemistry , receptor , psychology , psychotherapist
We investigated polymorphonuclear granulocyte (PMN) function in polycythemia vera (PV) in relation to healthy controls. PMN oxidative metabolism, assessed by chemiluminescence (CL), was significantly lower in PV patients after stimulation with leukotriene B 4 (LTB 4 ) and f‐Met‐Leu Phe (fMLP) (60% of control), whereas no difference in CL was seen after stimulation with phorbol myristate acetate (PMA) (120% of controls). Spontaneous and fMLP‐induced PMN adherence to an albumin‐coated plastic surface, as well as spontaneous migration and LTB 4 — and fMLP‐induced chemotaxis, were similar to controls. This suggests the presence of a stimulus‐specific defect in PMN oxidative metabolism in PV.